Treatment of prostatitis with bacteriophages. How to treat acute and chronic bacterial prostatitis Bacteriophages in urology

Infections of the genitourinary system, including prostatitis, tend to have a long and protracted course, and in half of the cases become chronic. Despite all the pharmacological possibilities of modern medicine, the effectiveness of their therapy undergoes some difficulties and does not allow to completely get rid of the causative agent of the disease. This requires the search for additional solutions to the problem, one of which is the treatment of prostatitis with bacteriophages.

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Indication for admission

Prostatitis is an infectious and inflammatory process of tissue prostate caused by various bacterial agents. It is extremely important to determine the specific type of pathogen for further drug selection. Indications for the appointment of bacteriophages in patients with this pathology are as follows:

• confirmed laboratory-bacterial nature of the disease;
• chronic variant of the course of prostatitis;
• ineffectiveness of treatment with a course of antibiotics;
• isolation of a culture of resistant (resistant to the main treatment) bacteria;
• the presence of temporary contraindications to the appointment of antibiotics (for example, severe intestinal dysbacteriosis, the presence of an allergic reaction, severe immune disorders);
• complications of prostatitis;
• concomitant infectious processes of other organs and systems;
• as a component of combination therapy;
• advanced or senile age, diseases accompanied by a decrease in the body's defenses;
• in young children;
• additional prevention of relapse or exacerbation chronic prostatitis.

Contraindications

There are no contraindications to the use of bacteriophages in prostatitis. The only exception is individual intolerance or sensitivity to any of the components of the drug by the patient.

A possible limitation of the dose and frequency of administration is required in patients with severe hepatic or renal insufficiency, since there is a high probability of impaired excretion of the substance from the body. In each case, the decision is made only by the doctor on an individual basis and after interpreting the relevant examination.

Benefits of bacteriophage treatment

bacteriophages

The main advantage of bacteriophages is the specificity of their action against a specific pathogenic bacterial agent. Moreover, there are also phage species that destroy certain variants within the species. In addition, combined polyvalent preparations are produced that can act on several pathogens at the same time, i.e. with a broad antibacterial effect.

Phage therapy is able to destroy bacteria resistant to antibiotics (including II-III generation cephalosporins, fluoroquinolones, which are often prescribed for urinary tract infections). In other cases, they are used even to minimize the use of antibacterial drugs and thus prevent the development of resistance. It is noted that the sensitivity of the pathogenic flora to the phage does not decrease and may even improve. The mechanism of this phenomenon has not yet been studied.

Bacteriophages are a group of viruses that have a negative effect on bacterial agents through lytic enzymes. Phages penetrate the cell, begin to multiply actively and destroy the cell wall. They act exclusively on pathogenic flora. This ensures the safety of the use of phages in relation to the preservation of normal intestinal microflora, in contrast to antibacterial drugs that cause dysbacteriosis.

The onset of action in bacteriophages is very rapid. Literally on the 2-3rd day evaluate the effectiveness. The general condition and well-being improves, body temperature decreases, painful symptoms, dysuric disorders, irritation associated with prostatitis gradually decrease, and quality of life indicators improve. Phages quickly penetrate into the blood and lymph, and are excreted from the human body to a greater extent through the kidneys, thereby additionally sanitizing the urinary tract. When compared with the effect of antibiotic treatment, bacteriophage therapy showed high clinical results and practically comparable data. The development of relapses in the future also has the same frequency in both groups of patients. In addition, high safety, easier tolerance makes bacteriophages an alternative choice of treatment for the elderly, with concomitant immunodeficiency conditions, children, etc.

Action of bacteriophages

In the presence of a bacterial agent that is sensitive to bacteriophage, the number of the latter begins to progressively increase, which can lead to a decrease in the dosage taken. The period of the phage in the blood is also lengthened. None of the known antibiotics has such abilities.

Bacteriophages do not have any toxic effects on the body of a man. They act simultaneously on other chronic foci of infection, even if they are asymptomatic.

The use of bacteriophages in the treatment of any form of prostatitis can cause a positive effect in terms of improving antitoxic, cellular and humoral immunity. Other favorable properties of phages have also been found. For example, the normalization of the exchange of iron and copper. In addition, bacteriophage therapy causes activation and triggers the antioxidant mechanism.

Another important advantage of bacteriophages over other pharmacological agents is their relative availability and low material costs required for their acquisition.

Varieties of funds

Prostatitis in men can be caused various types bacteria. Depending on this, there are several main types of bacteriophages that are able to treat this disease:

• Klebsiella (active against Klebsiella);
• coliproteic (bactericidal effect is directed against Escherichia coli, Proteus);
• staphylococcal (high sensitivity in staphylococci);
• Pseudomonas aeruginosa;
• streptococcal;
• combined;
• pyobacteriophage;
• sextaphage;
• intesti-bacteriophage.

Basic principles of therapy

The main condition for the effective intake of bacteriophages is the preliminary determination of the sensitivity of the isolated bacterial culture to the corresponding phage. To do this, it is advisable to examine the secret of the prostate gland in the bacteriological laboratory, in which pathogenic microorganisms (enterobacteria, staphylococci, Pseudomonas aeruginosa, streptococci, etc.) are identified. Less than half of the cases show mixed flora.

As a rule, bacteriophages for the treatment of prostatitis are used in liquid form (vials with solutions). They can be used orally, or used as a local therapy (washing, irrigation, lotions). The daily dose when taken orally is 100 ml. and is divided into 3 stages. Use the medicine strictly on an empty stomach. Locally, the phage solution is passed through the drainage into the lower urinary tract, the bladder, 50 ml 2-3 times a day. Duration of therapy - 10-14 days or more (on average - up to 20). This is necessary to achieve complete penetration of the agent into the prostate tissue. The disadvantage of the mode of using bacteriophages is the need for a daily 3-fold intake compared to 1-fold administration of fluoroquinolones. This fact can negatively affect the patient's adherence to the regular intake of the therapeutic drug.

The duration of therapy for a sluggish form of prostatitis is extended to 1-2 months, with periodic breaks between courses and repeated bacteriological studies of the prostate secretion in the laboratory.

It also provides for the possibility of delivering a bacteriophage to an infectious focus in the prostate tissue in the form of rectal suppositories, microclysters. For this purpose, more suitable combinations of phages acting on several pathogens at once. Candles are applied 2 times a day, morning and evening, for 12-14 days. For microclysters, 50 ml of the medicinal substance is used in the form of a ready-made solution, which is administered after bowel movements also twice a day for 7-10 days. Manipulation makes sense when isolating a population of bacteria introduced from the gastrointestinal tract (Enterococcus fecalis, Escherichia coli).

Gel forms are known, which include one or more bacteriophages, and which are applied externally, 2 times a day after hygienic manipulations.

The degree of activity of the agent is determined by its dilution, at which the wall of bacteria is destroyed. Thus, a titer value of 10 6 corresponds to the fact that the bacteriophage begins to act when diluted 1,000,000 times.

Sometimes, at the discretion of the doctor, bacteriophages can be added to the main antibiotic therapy or prescribed as a course immediately after it. Local treatment phages is applicable only in combination with their oral administration or with the main group of antibiotics (a representative of fluoroquinolones, doxycycline, cephalosporin), since it alone will not lead to complete eradication of the infectious agent. Phage therapy is perfectly combined with any groups of drugs, does not affect their pharmacodynamics and pharmacokinetics, while maintaining biological efficiency.

Are there side effects

Side effects as a result of the use of bacteriophages are not observed. The only adverse reactions may be allergic manifestations, in the form of rashes, urticaria, Quincke's edema, anaphylaxis, etc. In rare cases, dyspeptic disorders (nausea), discomfort in the stomach, mostly acquiring mild or moderate severity, are possible.

There are no data on cases of overdose of bacteriophages.

Among the methods presented by the possibilities of modern medicine, bacteriophages are the most gentle and at the same time safe, highly effective way to treat inflammatory and infectious processes in the prostate gland (prostatitis). In the conditions of increasing resistance of pathogenic microflora to the latest generations of antibiotics, this type of medicine becomes almost indispensable in the clinical practice of any medical specialist. In addition, the safe use of phages ensures their wide use in all categories of patients, incl. debilitated and with comorbidities.

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Prostatitis is an inflammatory disease that affects the prostate - the male reproductive organ, which performs a secretory function and regulates potency. In case of violation of his work, the representative of the stronger sex can become impotent or infertile. The causes of the disease are:

• Inactive lifestyle
• Prolonged sexual abstinence or too frequent sexual intercourse, interruption of sex
• Bad habits, unhealthy diet
• Infection

What is a bacteriophage?

Bacteriophages are found in almost any environment around us, some are already present in the human body, others are in the air, water, soil, food.

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Therefore, in one patient it may be effective, while in another it may not. But with the simultaneous use of antibiotics and bacteriophages, one can expect an increase in the effectiveness of both.

Indications for use

1. Pathologies of the gastrointestinal tract (cholecystitis, dysbacteriosis)
2. Inflammatory phenomena in newborns or young children
3. Infections after surgery
4. Eye infections
5. Infection prevention in the hospital

Description of medicines

To eliminate inflammation of the prostate gland, bacteriophages of various types can be used, because various bacteria can cause prostatitis. The choice of medicine occurs only after they have been determined. Consider what medications a doctor can prescribe.

Staphylococcal bacteriophage

Staphylococcal bacteriophage for prostatitis is produced only in the form of a solution, which must be taken orally or used externally. The product is produced in glass ampoules of 20 and 100 ml, in one package there can be 4-10 pieces of the first or 1 pc. second. The main active substance of the drug is a sterile filtrate of phagolysates of Streptococcus strains. Specifically for this medication, indications for admission can be called:

• Diseases of the ENT, respiratory tract, lungs
• Infections that entered the body during surgery
• Urological infections
• Infectious diseases of the digestive tract, dysbacteriosis
• Prevention of pathologies caused by streptococci

The instructions for use say that the solution must be taken orally, rectally or externally. It can also be used to wash the nose or mouth, inject medicine into the vagina, uterus. How to use Bacteriophage for prostatitis: for an adult, it is necessary to use 20-30 ml of the drug daily orally or 40-50 ml during enema. The duration of therapy depends on where the inflammation is located, the course of the disease, and ranges from 1 to 3 weeks.

If it is necessary to use lotions or irrigation, it is necessary to apply up to 200 ml of bacteriophage. With urethritis, the input occurs through drainage, 20-50 ml twice a day. When you need to get to the prostate gland, you can take it inside at the same time (2 times a day before meals) and do an enema (once in the evening).

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The only contraindication to taking Staphylococcal Bacteriophage is the patient's hypersensitivity to its components. Pay close attention to how the liquid looks, because. when it becomes cloudy, it cannot be used. The bottle with bacteriophages must be shaken before use and look for the presence of sediment (it, like turbidity, is formed by bacteria from the environment that got into the wrong use of the bottle). Hence a few rules for patients:

1. Wash your hands well before using the product
2. Treat the cap every time with alcohol-containing solutions
3. It is necessary to remove only the cap, and do not touch the inner cork
4. It cannot be placed inside on any surface
5. Do not leave the bottle open, store only in the refrigerator

Because from the instructions it is clear that the cork cannot be removed, how to draw up the medicine? You need to take a syringe and pierce the stopper with it. When opened, the product can be stored for its entire shelf life, but if the liquid becomes cloudy, get a new one. In a pharmacy, the Bacteriophage of this group is sold without a doctor's prescription.

Intensi bacteriophage

The method of application for the solution is as follows: 30-40 ml orally 1 hour before meals, repeat 4 times a day. The duration of therapy is 7-10 days. When enema, it is necessary to dilute the agent in a small amount hot water and enter into anus. It is necessary to carry out the procedure 1 time per day, preferably in the evening, before going to bed. After the administration of the drug, the patient needs to lie on his stomach for about 30-40 minutes so that the solution can be absorbed into the tissues.

Before starting the Intensive Bacteriophage enema, be sure to empty the intestines - naturally or with a cleansing enema. A combination of both methods is possible. For the prevention of infections, it is necessary to take a single dose of the drug once a day. The cost of one package is about 800 rubles, you can buy it without a prescription from your doctor.

Pyobacteriophage complex

A drug with antibacterial action. Its composition is a mixture of purified filtrates of various bacteria. Phage therapy with it is effective against streptococci, staphylococci and enterococci, Klebsiel pneumonia, etc. The drug has no effect on other types of microorganisms. It is available as a solution for oral or rectal administration.

With the solution, you can make applications and lotions, moisten tampons for vaginal or rectal administration. The exact dosage should be determined by the doctor, based on the patient's condition. Recommended are 30 ml of bacteriophage for internal use and 50 ml for enema. Duration of treatment - from 5 to 15 days. Side effects or cases of overdose with the drug are unknown.

It is necessary to store the bottle with the solution at a temperature of 2 to 8 degrees, the shelf life is 2 years. If a precipitate or cloudiness appears, immediately stop taking it and buy a new package.

Alternative to bacteriophages

The only analogues of bacteriophages can only be antibiotics. They are selected according to the sensitivity of bacteria with their active substances or stop at broad-spectrum drugs. With prostatitis, 4 groups of antibiotics are used:

• Tetracyclines (Doxycycline, Unidox Solutab). Negatively affect the digestive tract, but are usually well tolerated by patients.
• Penicillins (Amoxicillin, Augmentin). Inexpensive, quite effective, but resistance is quickly developed to them.
• Macrolides (Azithromycin, Fromilid). Penetrates best into the prostate tissues, practically does not have side effects
• Fluoroquinolones (Levofloxacin, Ofloxin). The most highly effective means, but therefore the most dangerous

Each of them can cope with a certain group of pathogens, as well as reduce the inflammatory process, and facilitate urination. At first, doctors can prescribe first-line antibiotics that have a wide list of actions, and after exact definition infections appoint another, with a narrower focus.

Antibiotics have a large number of side effects, which makes it impossible to take them for a long time. In addition, pathogens are able to develop resistance to most of them.

In a pharmacy, you can buy an antibiotic only with a doctor's prescription. He also prescribes a treatment regimen and chooses dosages that may be completely different from those indicated in the instructions.

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Normally, the prostate gland does not contain foreign microorganisms. Sometimes bacteria through the urinary tract or through the blood can enter the prostate and cause inflammation. This is how acute and chronic bacterial prostatitis. For a man, this is an extremely unpleasant and painful experience.

Causes of bacterial prostatitis

Bacterial prostatitis can be caused by 2 reasons - these are pathogenic and conditionally pathogenic microorganisms.

• Pathogenic bacteria include sexually transmitted infections such as chlamydia and gonococci. Sexually promiscuous individuals lead the risk group for specific prostatitis.
• Among nonspecific microorganisms in men over 35 years of age, prostatitis is most often caused by Escherichia coli. Usually the infectious process begins in the urethra and then ascends to the prostate. About 25-40% of the population are carriers of pathogenic staphylococci.

Staphylococcus colonizes the epidermis, where it may not show its presence for a long time. When it enters the skin wounds or damaged mucous membranes, the microorganism begins to show its pathogenic properties. Staphylococcus aureus in the prostate is often the cause of bacterial prostatitis.

Other opportunistic bacteria that cause prostatitis:

• staphylococcus hemolytic;
• Pseudomonas aeruginosa;
• klebsiella;
• Proteus;
• enterobacter;
• epidermal staphylococcus aureus.

With timely antibiotic treatment, in most cases, recovery occurs. It should be understood that a key factor in the development of nonspecific bacterial prostatitis is a decrease in immunity. In order to avoid relapses of the disease, it is necessary to strengthen the body's defenses.

Symptoms of bacterial prostatitis

With bacterial prostatitis, the clinical manifestations of the disease begin quickly. The patient may be disturbed by the general symptoms of inflammation in the body: chills, fever, redness of the skin.

In addition, there are local symptoms:

• blood in urine
• burning and pain when urinating
• weak urine stream
• difficulty emptying the bladder
• pain and burning in the lower abdomen, lumbar and sacral region of the back, in the perineum or testicles;
• pain during bowel movements and ejaculation;
• the presence of blood in the semen.

Diagnosis of the disease

Usually, the diagnosis of this disease is not difficult.

On examination, the doctor may find enlargement or tenderness of the lymph nodes in the groin. It is possible to detect fluid released from the urethra, swelling and tenderness of the scrotum. With a digital examination of the prostate, its enlargement is determined. With a chronic infection of the prostate gland, it will be felt softening. Palpation reveals a sharply painful, swollen, soft and warm prostate gland.

During a laboratory examination, signs of bacterial prostatitis will be noted in the urine: leukocytosis, the presence of bacteria is possible. Bacteriological analysis of urine will allow you to isolate the pathogen and determine it with prostatitis. possible increase in the level of leukocytes and erythrocyte sedimentation rate.

Treatment of bacterial prostatitis

Can bacterial prostatitis be cured? Treatment can and should be done. Timely appeal to the urologist will allow this disease.

Traditionally, antibiotics and anti-inflammatory therapy are used to treat bacterial prostatitis. The optimal treatment regimen includes the appointment of an antibiotic after determining the sensitivity of the pathogen. Prior to this, drugs for the treatment of prostatitis are selected empirically. Most often, drugs of the fluoroquinolone series are taken. These antibiotics have good tissue penetration and a wide spectrum of antimicrobial activity, including causative agents of bacterial prostatitis. Antibiotics in the treatment of acute prostatitis take 2-4 weeks.

Treatment of chronic bacterial prostatitis requires longer therapy. Antibiotics in this case are selected after determining the pathogen and its sensitivity to the drug. To achieve a therapeutic effect, combination therapy is required, which includes measures aimed at increasing immunity. Physiotherapeutic procedures are prescribed - electrophoresis, magnetotherapy, laser therapy, prostate massage.

Antibiotics have their drawbacks. One of them is dysbacteriosis. You can use an alternative treatment - bacteriophages. They do not have such a negative effect, which makes their use attractive. By nature, bacteriophage is an antimicrobial virus. It is selectively introduced into the pathogen. The bactericidal effect is manifested in the fact that multiplying inside the cell, phages cause the death of the microbe. Another advantage is that bacteriophage can prescribe in the presence of antibiotic-resistant bacteria.

Bacteriophages act more selectively than antibiotics. Therefore, treatment with phages requires mandatory identification of the pathogen. For example, a staphylococcal bacteriophage kills only staphylococci, and will not act on other pathogens. The treatment regimen for bacterial prostatitis with phages lasts 7-10 days. Bacteriophage for prostatitis is applied orally and topically as irrigations and lavages.

Sometimes bacterial swelling of the prostate gland makes it difficult to empty the bladder. In such cases, the installation of a urinary catheter is required. It can be placed through the abdomen (suprapubic catheter) or inside the urethra (urethral catheter).
The patient should take a large amount of liquid, about 2-4 liters. The flow of urine will help flush out microorganisms from the urethra and prostate.

With prostatitis, hot and spicy food is worth it.

Do not self-medicate! Do not treat prostatitis folk remedies! The decision on how to treat bacterial prostatitis and which antibiotics to use should be made by the doctor, as each case is unique.

Possible Complications

Untreated prostatitis threatens with a large number of complications.

• One of the complications of acute bacterial prostatitis is its transition to chronic bacterial prostatitis. This disease is complex and difficult to treat. can lead to infertility.
• With inadequate treatment, small pustules appear in the prostate tissue, which merge, and one large abscess is formed - an abscess of the prostate gland. This complication will require surgical treatment.
• If the swelling of the gland during inflammation is very pronounced, urinary retention may develop. This condition is dangerous because it can lead to rupture of the bladder or urethra. The ingress of urine and microorganisms into the abdominal cavity will lead to peritonitis, which can cause sad consequences.
• If bacteria manage to get from the prostate into the bloodstream, such a formidable complication as sepsis will develop. Treatment methods for this condition require long-term hospitalization in the intensive care unit, a combination of surgical debridement of infection foci and multicomponent general therapy.
• With purulent fusion of the prostate, the formation of fistulas with neighboring organs is possible. Treatment of such complications is very long and requires the intervention of a surgeon.

A complication of bacterial prostatitis is possible in every patient. Therefore, at the first signs of the disease, you should immediately consult a doctor.

Prevention of bacterial prostatitis

Although bacterial prostatitis can be cured, it is best to prevent it from occurring.

To prevent the occurrence of bacterial prostatitis, it is important to practice safe sexual behavior. Having a regular sexual life with one regular partner - best defense from prostatitis.

Physical education, refusal bad habits and a balanced diet help to maintain immunity for enough high level, which is also an important aspect in the prevention of bacterial prostatitis.

The course of male prostatitis often takes a protracted nature, requiring long-term and complex treatment. Since the main cause of the disease is a urological infection, antibiotic therapy is mandatory in all cases. One of its promising areas is bacteriophages in prostatitis, which have a number of advantages over antibiotics and have good efficiency.

Principles of action and benefits of bacteriophages in prostatitis

The positive antimicrobial effect of bacteriophages consists in their ability to destroy the membrane of pathogenic bacteria by introducing into the cell body and subsequent intensive reproduction. These drugs have a strict selectivity of action, as they are able to multiply only in a certain type of bacteria. Therefore, the treatment of prostatitis with bacteriophages can be started only when the composition of the pathological microflora is known.

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Unlike antibiotics, to which resistance and resistance develop over time, phage therapy can be prescribed even in cases where the bacteria that caused the disease turned out to be resistant to antibiotic therapy. In addition, this method of treatment has a number of other advantages:

• speed of action and deep penetration into the infectious focus;
• absence negative impact on beneficial intestinal flora;
• no side effects and contraindications;
• rapid elimination from the patient's body;
• compatibility with other groups of drugs.

The use of bacteriophages in the treatment of prostatitis

Course therapy with phages in this pathology can last from 7 to 10 days. It is possible both an isolated prescription of the drug, and a combined one, in particular, together with various groups of antibiotics. Bacteriophages for prostatitis are used orally according to the scheme recommended by the attending physician, as well as local therapy, in the form of irrigation and washing.

To date, many varieties of the drug have been synthesized, in particular, from such common infections as staphylococcus aureus, streptococcus, Pseudomonas aeruginosa and many others. Improvement of clinical analyzes occurs as early as 2-4 days, patients also note a decrease in pain and intoxication, dysuric phenomena and normalization of body temperature. One of the conditions for the effectiveness of phage therapy is the preliminary detection of the sensitivity of the microbial flora.

18 Feb 2015, 19:49

This drug is produced in the form of a solution for injection. Treatment is allowed only after shaking the vial. In wellness therapy, hygiene must be observed so as not to introduce infections. After the product is shaken, there should be no sediment in it, and the drug itself will become transparent.

In order for Sextophage to be effective with prostatitis, it is recommended to store it in the refrigerator. Before opening the vial, wash your hands well with soap and water. For disinfection, it is recommended to wipe the lid of the product with alcohol. Then you need to get a sterile syringe from a rubber stopper required amount substances.

Also, do not put the cork inside on the table and other surfaces so that bacteria do not settle on it. You should not keep the bottle open yet, after using the medication you need to close it.

This drug can be called one of the most effective in the treatment of prostatitis. Despite the fact that it is an antibiotic, it does not have a negative effect on the human body. The process of killing bacteria with this medication is from 15 to 60 minutes and depends on the type of microorganisms and the immunity of the patient.

The advantages of this medication in comparison with antibiotics include the following:

• Sextaphage does not have a toxic effect on the body, and therefore can be prescribed to patients who do not tolerate antibiotics;
• during treatment with a drug, the intestinal microflora is not disturbed, since the agent can only destroy bacterial cells;
• the drug does not affect the effectiveness of other medicines and is combined with all medicines.

This drug is available in cardboard boxes of 8 or 1 vial. 1 vial contains 100 ml of the substance. And if the drug is produced in 8 pieces, then its volume is 20 ml. You can also find on sale ampoules of 5 and 10 ml. The drug in the vial has a pink color with a greenish tint, but after shaking it becomes transparent.

This product is available in 20 ml bottles, which are placed in cardboard boxes.

What is remarkable about the solution "Sekstafag"? The reviews indicate that it is a polyvalent pyobacteriophage, which has the ability to specifically lyse the bacteria of streptococci, staphylococci, enterococci, Proteus, Klebsiella pneumonia, as well as Escherichia and Pseudomonas aeruginosa.

What else is the purpose of appointing "Sextafag" to the baby? Reviews indicate that this tool is actively used for the treatment and prevention of infected wounds and hospital infections.

Are there any contraindications for the medicine we are considering? According to the instructions, this drug should not be used only in the presence of hypersensitivity.

How should Sextaphage be injected into the nose? Reviews indicate that for purulent-inflammatory diseases of the throat, ear and nose, this medication is used in an amount of 2-10 ml three times a day.

In order to prepare for surgical interventions in proctology, drip enemas are used.

With keratoconjunctivitis and conjunctivitis, this medication is instilled into the eyes 2 drops four times a day, with a corneal ulcer - 5 drops, and with purulent iridocyclitis it is used in the amount of 8 drops every three hours. If necessary, for the treatment of such a disease, you can use the drug inside.

For gynecological diseases that are purulent-inflammatory in nature, the medication in question is injected into the uterine cavity every day at a dose of 5-10 ml.

If chemical antiseptics were used to treat wounds before using this medicine, then the cavity should be well washed with a sterile 0.9% sodium chloride solution.

Before applying the Sextaphage solution, you should evaluate its transparency and make sure that there is no sediment, as well as the integrity of the package. If the medicine becomes cloudy and the integrity of the pack is violated, it is prohibited to use it.

When opening the vial, all asepsis rules should be strictly observed. It is forbidden to store such a medicine. It must be used immediately after opening.

How much does the antibacterial solution "Sekstafag" cost? Reviews claim that its cost is about 740 rubles. If required, this drug can be replaced by such an analogue as "Bacteriophage". By the way, in pharmacies, the agent in question can be purchased under the name "Pyobacteriophage polyvalent purified" or simply "Pyopolifag".

Cystitis, causes and symptoms

A person consists of 10 trillion of his own cells and 100 trillion of microflora cells, including beneficial and so-called opportunistic bacteria.

Each type of microbe plays an extremely important role, protecting our body from adverse effects - but only if it does not go beyond its biotope. That is, beyond the limits of a particular organ or system.

For example, the rectum, crowning the gastrointestinal tract, is densely populated by the bacterium Escherichia coli, or Escherichia coli. There, Escherichia is in its place and honestly solves the task assigned to it.

But a stone's throw from the exit from the rectum, anus, that is, a few centimeters from it, is the urethra - the urethra, where the path of E. coli is ordered. The entry of this conditionally friendly bacterium into the urethra threatens with urethritis - inflammation of this tubular organ.

By the way, for this reason, urologists strongly do not recommend wearing thongs for young girls, and for older ladies too. After all, these spicy panties provide the shortest path from the anus to the urethra. Doctors call thongs like this: a path for Escherichia. But this is so, by the way.

If the Escherichia moves up the canal upwards, it gets to the bladder and causes cystitis. And so on, up to the kidneys. (Note that 80% of all cystitis lies on the conscience of Escherichia coli. The remaining 20% ​​are due to saprophytic staphylococci, Klebsiella, Proteus and Pseudomonas aeruginosa).

In women, the urethra is much shorter and wider than in men. Therefore, it is much easier for E. coli to colonize the female urethra than the male one.

The male canal is long and tortuous, its mucosa is protected by local immunity. However, when it is weakened (which, for example, hypothermia, prolonged consumption of spicy foods and alcohol, stress, diabetes, prostatitis and much more), Escherichia marches along the urethra, reaching the bladder and hitting its walls.

It is not difficult to guess that the easiest way for a man to get cystitis is through intimate contact with a woman suffering from the same ailment. It seems to be not a venereal disease, this cystitis (doctors are categorically against writing it down as an STI).

However, the fact remains: unprotected sex (often messy - after all, you won’t ask your partner, throwing off everything superfluous from her, if she has cystitis) is one of the main reasons for the defeat of the male bladder.

... And if unprotected sex was also anal, then the likelihood of infection of the urethra with Escherichia coli and, accordingly, the likelihood of cystitis increases significantly ...

How does cystitis manifest in men? Yes, basically the same as for women. Frequent urge to urinate, especially at night, is often ineffectual. Cutting during the administration of a small need, pulling pains above the pubis, oppressive sensation of an unemptied bladder.

As a result - a depressed state and the extinction of libido. What sex? What kind of women? Even the work you love is disgusting. All attention is switched to the lower abdomen. On the bladder.

Cystitis home treatment

There is no need to panic, however. In the presence of these symptoms, doctors do not advise immediately rushing to medications. What you need to do is drink as much as possible - to wash the infection from the walls of the bladder.

Drink and drink again. But not beer and not even cocoa with tea. The number one drink for cystitis is cranberry juice. It has the magical ability to deprive E. coli of the ability to stick to the mucosa.

Cowberry water, which was so adored by the sun of Russian poetry A.S., has a similar effect. Pushkin.

If it is not possible to get these berry drinks, lean on sour-milk ones.

You need to drink 8-10 glasses a day, no less. And to urinate at the first urge, without delay for a minute, literally squeezing out the infection.

If no improvement is observed within a week of such therapy, you should contact your urologist.

You must run to him immediately, with all your might, if:

• you are feverish;
• urine became cloudy, with flaky sediment;
• blood is observed in the urine (the so-called hematuria).

If you ignore these symptoms, walk past the urologist's office out of false shame or stubborn pride, the acute phase of cystitis will turn into a chronic one. And it often proceeds latently, that is, hidden, only occasionally reminding of itself.

But E. coli and others like it will not doze all this time! Someday, microbes will get through the ureters to the kidneys - and things will take a completely different turn.

Treatment of cystitis with bacteriophages

Total posts: 541

05/31/2012, Anna Hello. I am 24 years old. I got sick with cystitis last year, at first I didn’t know what it was, so it developed into an acute form. When I came to a private clinic, the urologist unequivocally said that I needed to drink antibiotics. But I'm holding on healthy lifestyle life and I try not to use strong medicines, so as not to harm my health even more.

So I listened to the advice of my sister, who experienced it myself. She advised me before taking antibiotics, to give the body the opportunity to overcome the infection itself. To do this, you need to stop eating a short time so that the body directs all its forces to fight the disease. I fasted for 3 days, only drank water.

05/17/2012, Tatyana Hello. I am 25 years old. cestitis began in the 9th grade. that I just haven't tried. all to no avail. the worst pains. I realized that when the first symptoms of cystitis begin, you should immediately drink plenty of water and go to the toilet every 10-15 minutes. urine washes away the infection and the pain becomes less painful.

05/14/2012, Ekaterina Treated cystitis by a urologist with kanefron and 5 legs, to no avail. Moreover, the tests and ultrasound were good, but at the same time pain, cramps and burning. A week later (which was waiting for tests), there was visible blood in the urine at the end of urination and slight tingling in the lower abdomen, just in the middle. The doctor prescribed these medicines only at my request, since the urine test was good.

I spent a week on drink - it does not help. I began to drink cranberry juice - less cramps, but the blood in the urine did not disappear. I drank Monural sachet without permission, as it should be at night, after 3 hours of eating, urinating. It helped, but only until lunch. I bought another bag for the night - only a burning sensation appeared in the vagina. Having read that it can still be associated with gynecological and venereal diseases, I went to the gynecologist. the ultrasound is good. I'm waiting for the tests.

In the meantime, I decided to drink a couple of drops of Hilak-Forte to normalize the intestinal microflora after Monural. I don’t know if it’s from them or because I continued to drink Kanefron and 5 legs all this time, but I felt better. Not quite yet, but there is no blood in the urine. You can’t sit in a hot bath yet - this provoked incomprehensible bleeding for one day.

In general, I read about Hilak-Forte and it contains the E-coli bacterium, which causes most cystitis. And Khilak-forte is a bacteriophage, which is used in the treatment of cystitis, including. If it helps finally, then it's good. Only now it is spelled antidiarrheal, but I have diarrhea from it, on the contrary. But this is nothing compared to cystitis.

05/09/2012, Elena suffers from the same disease. Elmiron did not help. 2 courses of Hepan instillations made life easier.

05/03/2012, Polka24 Well, when I was treating my cystitis, I checked for all the infections that could cause it, and already treated everything that was possible, and he, the infection, then returned several times (here's what I will say - it is necessary to do prevention, so that there are no relapses, there is a drug monurel (exactly as it is written), it is just for the prevention of cystitis, well, to consolidate the results of treatment, it is taken in acute.

04/27/2012, Sasha Dear women. Cystitis causes latent infection ureaplasma. It is necessary to treat it and it will pass, it can be sexually transmitted from a partner, it must be treated accordingly, until you are cured, any draft will exacerbate your cystitis. and furagin helps to relieve symptoms very well, 2 tablets each.

3 times a day, the Urological collection (Fitonefrol) still works well. there is also a suspension for dilution in water - Phytolysin, but it is an amateur (very nasty herbal taste), but it is effective, with Furagin you can take a No-shpy tablet to relieve spasms. If there is a very strong exacerbation, Monural helps, there is 1 tablet, you take it and after a couple of hours everything goes away, but this helps only with a one-time inflammation, it won’t get rid of it forever, you need to treat the infection.

07/13/2012, Olga Mikhal 22 I have had cystitis for 6 years, my tests are good, I had ureaplasmosis, my husband and I were treated, ureaplasma disappeared, but cystitis remained. So I don't think these diseases are related. Despite the fact that my urine and blood tests are good. There are no infections.

04/18/2012, Lyudmila, 56 years old Women. Who tried the drug "Detruzitol" pharmacy-Italy.

I read in Aibolit. the woman advised him to take it .. He is not in Kyrgyzstan

05/02/2012, hope I am 57 years old. I caught cystitis recently. I think from nervous stress. I drank nolicin and lingonberry collection. After 5 days it all started all over again. Who has experienced recovery, write.

05/31/2012, Anna Hello. I got sick with cystitis last year, at first I didn’t know what it was, so it developed into an acute form. When I came to a private clinic, the urologist unequivocally said that I needed to drink antibiotics. But I adhere to a healthy lifestyle and try not to use strong medications so as not to harm my health even more.

So I listened to the advice of my sister, who experienced it myself. She advised me before taking antibiotics, to give the body the opportunity to overcome the infection itself. To do this, you need to give up food for a short time, so that the body directs all its forces to fight the disease. I fasted for 3 days, only drank water. On the fourth day I woke up completely healthy. I have not taken a single pill and to this day there are no signs or even hints. I advise everyone.

Sources used: www.sikirina.tsi.ru

Hi all! Today I want to write about such a drug, it is called Sextafag. Have you heard? I found out about him relatively recently, although I talked to many people about him, they have been accepting or accepting him for a long time. That is, even in childhood diseases of the ENT organs, it is actively used. But I have a different “topic” - cystitis (((As in my youth I started to get sick with it, this has been going on for ten years for me for sure.

This is how I am treated from time to time with antibiotics and, in principle, everything was successful, but here recent times I began to notice that there is no such efficiency as before. That is, if you start taking an antibiotic earlier and immediately relief comes, pain and pain disappear, and you yourself understand how important it is. I voiced all my thoughts to the doctor, to which she told me that due to addiction, antibiotics simply cease to help so well, so in parallel with them, she told me to take Sextafag. Having studied everything at home about this drug, from what and for what it is, in the morning I went to buy it. The box looks like this.

Here is the reverse side.

Instructions as always, which do not forget to read.

Reverse side of instructions.

And inside here are such bottles in the amount of 4 pieces.

These are bacteriophages that destroy different kind bacteria. Those. in chronic cystitis, bacteria are already resistant to antibiotics, but not to bacteriophages. Therefore, taking this kind of drug will help cure cystitis much faster and more efficiently.

A huge plus of this drug is that it does not cause any dysbacteriosis, does not suppress the immune system and is fully compatible with taking other drugs.

Before use, this bottle must be shaken and checked to ensure that it is not cloudy. The solution must be transparent.

The solution is used inside. The dosage is prescribed by the doctor.

You probably saw the cost of the drug on the box - 766 rubles. Yes, not cheap, but believe me, the effectiveness of treatment is much higher and better. And when you have pain and cramps, you will not spare any money to get rid of them.

Autumn has come, it's cold. Many during this period and begin to hurt. I advise everyone to dress warmly and still spend money to protect yourself from cystitis. But if cystitis still comes up, keep in mind about Sextafagus and be sure to talk about it with your doctor.

Sources used: obzorka.net

Infections of the genitourinary system, including prostatitis, tend to have a long and protracted course, and in half of the cases become chronic. Despite all the pharmacological possibilities of modern medicine, the effectiveness of their therapy undergoes some difficulties and does not allow to completely get rid of the causative agent of the disease. This requires the search for additional solutions to the problem, one of which is the treatment of prostatitis with bacteriophages.

I heard about the existence of such a disease as cystitis when I was probably still a schoolgirl. I would never have thought that cystitis would affect me personally. And that I would get rid of it in a matter of days with a drug called Fagogin.

One fine evening (although this epithet is absolutely inappropriate here), while visiting the toilet, I suddenly noticed that the urine had become slightly cloudy, and the saddest thing was that it had some strange, unpleasant smell.

I have no third-party sexual contacts, my husband and I have been living in peace and harmony for eight years now. That is, a venereal disease was out of the question. Then what is it?

Without thinking twice, I went through an old notebook and found the phone number of a classmate who worked in one of the district antenatal clinics and, according to rumors, had a degree. With difficulty guessing the half-erased numbers written in pencil, I dialed the number.

Oddly enough, Sveta recognized me right away. After chatting for a couple of minutes common topics remembering school years, we got down to business. Svetka, that is, Svetlana Ivanovna, made an appointment for me the next morning.

At nine in the morning I was already standing in line for tests at the LCD. It turned out that I have Staphylococcus aureus above the norm. This microbe is present everywhere, including in the human body. If his quantitative indicator is in order, then he is not dangerous. But if the "population" of Staphylococcus aureus goes off scale, then it can easily cause unpleasant diseases. For example, cystitis - as in my case.

How to get rid of chronic cystitis?

Bacterial resistance to various groups of antibacterial drugs is currently considered one of the most pressing problems in all areas of medicine. Urological diseases also do not stand aside: in particular, chronic recurrent cystitis is currently considered to be not only the most common disease of the genitourinary system, but also the most difficult to treat. drug treatment disease.

Main causes of antibiotic resistance

Unjustified use of antimicrobials in medicine. It is possible to discuss this problem for a very long time, in this matter there are “merits” of doctors, pharmacists, and patients. In particular, empiric antibiotic therapy can be mentioned - undoubtedly, this method is extremely important, and sometimes extremely necessary for the treatment of acute infectious and inflammatory diseases, however, it often becomes an essential prerequisite for further development resistance of bacterial strains.

Insufficient stock of antibiotics. Despite the progressive development of the pharmaceutical industry, only a few cases of the synthesis of new drugs can be recalled over the past 20 years. Given the fact that the arsenal for the treatment of cystitis is limited to only 3-4 main groups of antibiotics, it follows that this arsenal will soon exhaust itself.

As mentioned above, the frequency of chronic recurrent forms of cystitis is steadily increasing, which is primarily due to incorrect and unsystematic treatment. Returning to the question of the resistance of strains of E. coli, Proteus, Klebsiella and Staphylococcus, it is enough to recall the All-Russian epidemiological study "DARMIS" on the antibiotic resistance of uropathogens, which was carried out by a Russian research group in 26 regional centers and 18 cities of Russia in 2010-2011: even then, the results showed that that fluoroquinolones and protected penicillins have lost much of their potency. At present, in urological practice, there is already a very noticeable trend towards a decrease in the effectiveness of fosfomycin and cephalosporins of the 3rd generation.

1. Rational use of available antimicrobials; 2. Expanding the possibilities of drug therapy

If everything is very clear regarding the first point, then the second has several options.

Option one is herbal medicine, which over the past decades has been considered an essential addition to antibiotics in the treatment of urinary tract infections. However, it does not have a direct effect on the pathogen, has no evidence base, and is often powerless against recurrent forms of the disease.

The second option is the use of bacteriophages. This group medicines not new, but not so widely known. Bacteriophages are fundamentally different from standard antibiotics in that they are antibacterial agents that selectively kill certain bacteria, but do not interact with human cells in any way.

Firstly, this group is considered an excellent alternative for those patients who do not respond to antibiotics, as well as for those for whom antibiotics are contraindicated (allergic reactions, pregnancy, childhood, severe liver and kidney disease).

Secondly, they have practically no systemic effect on the body, there is no violation of the intestinal microflora and suppression of immunity.

And, thirdly, bacteriophages are easier to use (produced in liquid form in vials), which is especially important for those who are contraindicated in tablets (for certain diseases of the stomach, intestines, liver). Bacteriophages are convenient for ingestion, as well as for washing and rinsing.

In the treatment of chronic cystitis, when antibiotics do not help, doctors increasingly prefer the bacteriophage drug Sextafag, which selectively affects Escherichia coli, Proteus, Klebsiela, Staphylococcus aureus. It can act as an addition to the main course of antibiotics, or be used as the only drug.

Prevention and more prevention!

Despite the modern possibilities of drug therapy for cystitis and other diseases, prevention always remains at the forefront. Learning to prevent a disease is the first thing a patient must learn, and in this case, neither antibiotic resistance nor recurrence of the disease will be as important as they are now.

Dolganov I.M., urologist-andrologist of the first category, employee of the Department of Urology and Surgical Andrology of the Russian Medical Academy of Postgraduate Education.

Sources used: www.medlinks.ru

Cross-drug interactions

Sextaphage really helped with cystitis, unlike antibiotics

I will remember this autumn not only for the cold weather and slippery roads, but for the troubles due to the fact that I got a bad cold. I went to a concert with my friends in a light jacket and dress, and as a result I got cold, and cystitis began. Moreover, the first symptoms began the very next day, but I ignored them, drank painkillers, and forgot about it at work. A couple of days later, the whole bottom was seized so that by the evening I was simply bent over from pain.

At home, I took an antibiotic, the next day, too, relief came, but the pain did not go away. After a course of antibiotics, literally a week later I again felt aching pains in the lower abdomen and went for a consultation with a doctor. He was not surprised by this situation, saying that antibiotics do not always help in this case, often the body already has an addiction, and not all bacteria are killed.

Therefore, he prescribed the drug Sextafag with a different principle of action than antibiotics. As I read at home, its active ingredient is bacteriophages, which infect only bacterial cells that cause an exacerbation of cystitis, while they are not addictive and act on bacteria that are already resistant to antibiotics. I took Sextafag according to the doctor's prescription and after it I was finally cured, the pain has not bothered me for a month, no relapses.

I can say about the drug Sextafag itself that it has been widely known for a long time, but I learned about it for the first time and am very glad, because it really helped me.

The principle of its work is the destruction of bacteria, while its bacteriophages do not destroy other cells, but exit the body unchanged through the kidneys.

I was also very pleased that after drinking Sextafag there were no problems with the stomach and I did not suffer from dysbacteriosis. After the same antibiotics, I always have to carry something antidiarrheal with me.

Therefore, girls, take note of my experience, Sextafag is an excellent remedy for cystitis, especially for those who are no longer helped by antibiotics.

Sources used: irecommend.ru

200 mg No. 10 - 700-750 rubles.

Methods of using tablets

In cases where synthetic antiseptics were used to treat wounds, preliminary washing with sodium chloride (0.9%) is recommended. For babies, you can mix the medicine with mother's milk and give it to drink, provided that the baby does not vomit. In severe pathologies, a combined intake is prescribed: rectal and oral. The course is from 5 to 15 days. In case of recurrence, the treatment is repeated.

How to use Sextafag and dosing regimen

Therapeutic and prophylactic bacteriophages contain polyclonal virulent bacteriophages with a wide range of action, including active against bacteria resistant to antibiotics. Phage therapy can be successfully combined with the prescription of antibiotics.

At present, bacteriophage preparations are produced in Russia against the main pathogens of nosocomial infection, such as staphylococcal, streptococcal, Klebsieleus, Proteus, Pseudomonas aeruginosa, coliphage (NPO Immunopreparat, Ufa; enterprise for the production of bacterial preparations, Nizhny Novgorod;

Phage therapy was used mainly in the treatment of chronic infectious and inflammatory urological diseases: chronic cystitis, chronic pyelonephritis, chronic prostatitis, urethritis, suppuration of wounds, in some cases in acute purulent-septic conditions of patients - a total of 46 people. Liquid bacteriophages were used for treatment: Pseudomonas aeruginosa, Proteus, coliphage, staphylococcal and combined pyobacteriophage containing the listed phages.

The overall bacteriological efficacy was over 84%, clinical - over 92%. The clinical efficacy of phage therapy is almost comparable to the activity in the control group of patients who were treated with modern antibiotics - fluoroquinolones.

Sources used: medi.ru

In severe manifestations of infections caused by staphylococci, streptococci, Proteus, Klebsiella pneumonia, Pseudomonas aeruginosa and Escherichia coli, Sextafag ® is prescribed for treatment as part of complex therapy.

As a prophylactic measure, the bacteriophage Sextaphage ® is used to treat surgical and freshly infected wounds, as well as to prevent nosocomial infections according to epidemic indications.

An important condition effective treatment(phage therapy) drug Sextafag ® is a preliminary determination of phagosusceptibility of the pathogen.

None.

In the treatment of bacteriophage Sextaphage ® is used depending on the nature of the focus of infection:

1. Locally in the form of irrigation, lotions and plugging with liquid phage in an amount of up to 200 ml, depending on the size of the affected area. In abscesses, the bacteriophage is introduced into the cavity of the focus after the removal of pus by puncture. The amount of the injected drug should be slightly less than the volume of the removed pus. In osteomyelitis, after appropriate surgical treatment, a bacteriophage is poured into the wound in 10-20 ml.
2. Introduction to the cavities - pleural, articular and other limited cavities up to 100 ml of bacteriophage, after which capillary drainage is left, through which the bacteriophage is re-introduced for several days.
3. With cystitis, pyelonephritis, urethritis, Sextafag ® is taken orally. If the cavity of the bladder or renal pelvis is drained to remove fluids, the bacteriophage is injected through a cystostomy or nephrostomy 1–2 times a day, 20–50 ml into the bladder and 5–7 ml into the renal pelvis.
4. In purulent-inflammatory gynecological diseases, Sextafag ® is injected into the cavity of the vagina, uterus at a dose of 5–10 ml once daily.
5. In purulent-inflammatory diseases of the ear, throat, nose, the drug is administered at a dose of 2-10 ml 1-3 times a day. Bacteriophage is used for rinsing, washing, instillation, introduction of moistened turundas (leaving them for 1 hour).
6. With conjunctivitis and keratoconjunctivitis, the drug is instilled 2-3 drops 4-5 times a day, with a purulent corneal ulcer - 4-5 drops, with purulent iridocyclitis, the drug is used 6-8 drops every 3 hours in combination with ingestion.
7. In the treatment of stomatitis and chronic generalized periodontitis, the drug Sextafag ® is used in the form of mouth rinses 3-4 times a day at a dose of 10-20 ml, as well as the introduction of turundas soaked with pyobacteriophage into periodontal pockets for 5-10 minutes.
8. In intestinal forms of the disease, diseases of internal organs, dysbacteriosis, the bacteriophage is used by mouth and in the form of enemas for 7-20 days. Bacteriophage is given through the mouth 3 times a day on an empty stomach 1 hour before meals. In the form of enemas, it is prescribed 1 time per day instead of one dose by mouth.

Active ingredient: Pyobacteriophage

Producer: Perm Federal State Unitary Enterprise Microgen,

Sextophage is a polyvalent composition belonging to drugs from the immunobiological group. A drug of systemic action, designed to destroy a certain category of pathogens, including Escherechia and staphylococci. Suitable for oral, external and rectal use (lotions, tampons, oral administration, nose and eye drops, irrigation, inhalation), can be used during pregnancy, for the treatment of children.

Solid form - Sextafag tablets with an acid-resistant thin film. In addition to pyobacteriophages, the composition includes sodium alginate, calcium carbonate, lactose, glucite, methylcellulose. All auxiliary mixtures increase the activity of filtered viruses in the preparation.

It is worth noting that this medication has practically no contraindications, except for the manifestation of an allergic reaction. It can be used for treatment at any age in the presence of chronic or acute diseases. Also, many people replace prohibitive drugs with this medication. For example, during pregnancy or cystitis, antibiotics are contraindicated, then Sextafag can replace them.

In the event that, after shaking, the drug has a cloudy tint, it is not worth using it, most likely, the medicine is spoiled. Also, this color of the drug may indicate the penetration of bacteria into it, which will further provoke complications of the disease.

The cost of this drug is about 1000 rubles. One of its shortcomings can be called the fact that the drug has no analogues. And as patients say, not all pharmacies can buy it because it is not so popular.

Sextaphage is one of the effective and safe drugs for the treatment of prostatitis caused by a bacterial nature. Distinctive feature This medicine can be called the fact that thanks to this medicine it is possible to overcome many diseases. Often, patients want to be cured of prostatitis, and many other diseases are cured.

None.

According to the instructions, Sextafag is used to prevent nosocomial infections and to treat freshly infected wounds.

According to the instructions, Sextafag is contraindicated only in case of hypersensitivity to the drug.

As a prophylactic measure, the bacteriophage Sextaphage ® is used to treat surgical and freshly infected wounds, as well as to prevent nosocomial infections according to epidemic indications.

None.

Price and where to buy a sextaphage?

For search, you can also use the site

http://www.poisklekarstv.ru BACTERIOPHAGE IS A SAFE ALTERNATIVE TO ANTIBIOTICS. THERE ARE CONTRAINDICATIONS, CONSULT A PROFESSIONAL BEFORE USE.

Despite the variety of drugs offered for chemotherapy of bacterial diseases (over 600 items, of which more than 100 antibiotics), urinary tract infections still rank first among all hospital-acquired infections.

Difficulties in the treatment of urological infections are due to many factors. The introduction of endoscopic interventions (both therapeutic and diagnostic) and high technologies in urological practice, in addition to positive aspects, has introduced a number of problems: new entry gates of infection have opened, the number of operated patients of elderly and senile age with weakened immunity has increased.

Permanent drains, stones, and residual urine serve as colonization and breeding grounds for hospital microbiota. The predominance of the role of opportunistic microorganisms in the development of hospital urological infection has led to a decrease in the effectiveness of treatment and created difficulties in the selection of therapeutic drugs, especially for patients suffering from chronic inflammatory diseases of the kidneys and urinary tract.

Initial, natural, resistance to old antibiotics does not disappear, and bacteria gradually improve resistance mechanisms and develop protection factors against new groups of antibiotics, such as 3rd generation cephalosporins or fluoroquinolones. Antibiotics create a selective background for the gradual spread of strains of microorganisms resistant to them and the wide distribution of information exchange mechanisms in nature.

Antibacterial treatment can cause the development of dysbacteriosis. In the case of the use of antibiotics against the background of the developed dysbacteriosis of the intestinal tract, antibacterial therapy can increase the degree of its severity. In addition, antibiotics reduce the colonization resistance of the intestine, increase the permeability of the intestinal wall, facilitating the penetration of opportunistic microorganisms into the bloodstream, internal organs and the development of a secondary focus of infection. Bacteriophage preparations have good prospects as antibacterial therapy.

Therapeutic and prophylactic bacteriophages contain polyclonal virulent bacteriophages with a wide range of action, including active against bacteria resistant to antibiotics. Phage therapy can be successfully combined with the prescription of antibiotics.

At present, bacteriophage preparations are produced in Russia against the main pathogens of nosocomial infection, such as staphylococcal, streptococcal, Klebsieleus, Proteus, Pseudomonas aeruginosa, coliphage (NPO Immunopreparat, Ufa; enterprise for the production of bacterial preparations, Nizhny Novgorod;

MP "Biofon", Saratov). The advantage of these drugs lies in the strict specificity of the action, since they cause the death of only their specific type of bacteria, without affecting, unlike antibiotics, the normal intestinal microflora of the patient. The use of bacteriophages has shown good results in the treatment of dysbiosis, surgical, urogenital, ENT infections.

Domestic neonatologists have shown the high efficiency of phage therapy for purulent-septic infections in children early age. In addition to the lytic effect on microbes, their importance in the mechanism of antitoxic, cellular and humoral immunity is noted.

At the Research Institute of Urology, MHMP RF, together with the Research Institute for Standardization and Control of Medical and biological preparations them. L.A. Tarasovich and NPO "Immunopreparat" during 1993-1994. a study was made of the clinical efficacy of bacteriophage preparations in the treatment of patients with inflammatory urological diseases.

Phage therapy was used mainly in the treatment of chronic infectious and inflammatory urological diseases: chronic cystitis, chronic pyelonephritis, chronic prostatitis, urethritis, suppuration of wounds, in some cases in acute purulent-septic conditions of patients - a total of 46 people. Liquid bacteriophages were used for treatment: Pseudomonas aeruginosa, Proteus, coliphage, staphylococcal and combined pyobacteriophage containing the listed phages.

Satisfactory clinical analyzes were obtained already on the 2-4th day of treatment with bacteriophages: a decrease in the symptoms of general intoxication, dysuria, a decrease in body temperature, and an improvement in bowel function (especially in children).

The overall bacteriological efficacy was over 84%, clinical - over 92%. The clinical efficacy of phage therapy is almost comparable to the activity in the control group of patients who were treated with modern antibiotics - fluoroquinolones.

Thus, bacteriophage therapy for urinary tract infections is effective. independent view treatment or may be used in combination with antibiotic chemotherapy.

Being harmless biological method treatment, bacteriophage therapy can be used in young children. To obtain positive results from the use of bacteriophages, a preliminary study of the sensitivity of microorganisms to them is necessary. When using bacteriophages in large clinics, it is advisable to include in the composition of industrial strains on which commercial preparations are prepared, hospital strains of causative agents of purulent-inflammatory diseases characteristic of this hospital.

Useful pyobacteriophage virus - indications, instructions for use, reviews, price

Most of the reviews about this medication are positive. In the treatment of this drug, consumers note a significant effect, especially in the treatment of dysbacteriosis and purulent infections of the respiratory system. Also, the advantages of this medicine include the possibility of its use in young children.

Among the shortcomings of the drug, patients indicate its high cost.